| Single Strike & Rapid Strike Premium Trainer Boxes | Jan 22, 2021 | Japanese |
| Rapid Strike Master | Jan 22, 2021 | Japanese |
| Single Strike Master | Jan 22, 2021 | Japanese |
| McDonald's Collection 2021 | Feb 9, 2021 | English |
| Shining Fates | Feb 19, 2021 | English |
| Matchless Fighters | Mar 19, 2021 | Japanese |
| Battle Styles | Mar 19, 2021 | English |
| Silver Lance | Apr 23, 2021 | Japanese |
| Silver Lance & Jet-Black Spirit Jumbo Pack Set | Apr 23, 2021 | Japanese |
| Jet-Black Spirit | Apr 23, 2021 | Japanese |
| Inteleon VMAX High-Class Deck | May 28, 2021 | Japanese |
| Eevee Heroes | May 28, 2021 | Japanese |
| Eevee Heroes VMAX Special Set | May 28, 2021 | Japanese |
| Gengar VMAX High-Class Deck | May 28, 2021 | Japanese |
| Chilling Reign | Jun 18, 2021 | English |
| Skyscraping Perfection | Jul 9, 2021 | Japanese |
| Sword & Shield Family Pokémon Card Game | Jul 9, 2021 | Japanese |
| Blue Sky Stream | Jul 9, 2021 | Japanese |
| V-UNION Special Card Sets | Aug 20, 2021 | Japanese |
| Evolving Skies | Aug 27, 2021 | English |
| Fusion Arts | Sep 24, 2021 | Japanese |
| Celebrations | Oct 8, 2021 | English |
| 25th Anniversary Collection | Oct 22, 2021 | Japanese |
| Promo Card Pack 25th Anniversary Edition | Oct 22, 2021 | Japanese |
| 25th Anniversary Golden Box | Oct 22, 2021 | Japanese |
| Zacian & Zamazenta vs Eternatus Special Deck Set | Nov 5, 2021 | Japanese |
| Fusion Strike | Nov 12, 2021 | English |
| Creatures 25th Anniversary History Deck | Dec 1, 2021 | Japanese |
| VMAX Climax | Dec 3, 2021 | Japanese |
| Start Deck 100 | Dec 17, 2021 | Japanese |
